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Breast Cancer

Breast cancer is a growth of malignant cells within the breast tissue. Most breast cancers form in the milk ducts or lobes of the breast. There are two types of cancers, non-invasive (or in-situ) which have not spread to the surrounding tissue or other parts of the body and invasive cancers which have spread elsewhere.

Breast cancer will usually first spread to lymph nodes within the breast and the armpits. It may also spread to other areas of the body including the bones, liver, brain and lungs. Tumours in these locations are called 'secondary tumours'.

Some facts and figures

  • Breast cancer is the most commonly diagnosed cancer in Australian women
  • 1 in 11 Australian women will develop breast cancer before the age of 75 (1)
  • The lifetime risk of an Australian woman dying from breast cancer is 1 in 56 (2)
  • In 2003, there were 11 788 cases of female breast cancer in Australia, accounting for 28.2% of cancer cases in women (3)
  • In 2003, 2 710 women died from breast cancer, 16.3% of all female cancer deaths (4).

The incidence of breast cancer is slowly increasing, partly as a result of improved detection through the introduction of mammographic screening. The age standardised rate of cancer incidence rose from 89.5 cases in 1998 to 111.8 cases in 2003 (5). The mortality rate for breast cancer has increased by 3.8% between 1993 and 2003 (6).

Risk factors

As yet, it is not known what causes breast cancer, although some groups of women seem to be at greater risk than others. There does appear to be an association between some clinical and lifestyle factors in women's lives and the risk of breast cancer. It is likely that these factors work together to trigger breast cancer, rather than there being a single cause.

The major risk factor associated with breast cancer is age. Women aged 50 and over made up approximately 76% of breast cancer cases in 2002 (7).

Other factors indicating a higher than average risk of breast cancer include:

  • a personal history of breast cancer
  • a family history of breast cancer or ovarian cancer (mother, sister or daughter)
  • genetic susceptibility (carrier of the genetic mutations BRCA1 and BRCA2)
  • early start of menstruation (before the age of 12) or late menopause (at age 55 or later)
  • never had any children, or had first child after the age of 29
  • previous benign breast disease
  • alcohol consumption
  • excess weight after menopause
  • oral contraceptive pill and hormone replacement therapy (8).

Australia's incidence and mortality rates compared to rest of the world

There is considerable variation around the world in breast cancer incidence and mortality. It is thought that environmental rather than genetic factors play a role in this variation, since the incidence rates of breast cancer amongst a migrant group generally shift to match those of the local population, rather than the population of the migrant group's country of origin (9).

Age standardised incidence and mortality rates per 100 000 for 2002 (10)

  Incidence Mortality
Australia 83.2 18.4
USA 101.1 19.0
Canada 84.3 21.1
New Zealand 91.9 24.5
United Kingdom 87.2 24.3
Northern Europe 82.5 22.6
Southern Europe 62.4 18.1
South-Eastern Asia 25.5 11.8

Breast cancer prevention

The major effort in the fight against breast cancer has been directed at establishing an effective breast cancer screening program, based on the fact that breast cancer is more likely to be cured if found early. There are two main components to an effective screening program:

  • Breast self awareness
  • Regular mammography for women in appropriate age groups.

Women are encouraged to become familiar with their breasts so that if a change occurs they are more likely to notice it. Signs of breast cancer include:

     

  • lump, lumpiness or thickening of the breast
  • change in size or shape of the breast
  • dimpling or puckering of the skin on the breast
  • rash on the nipple or around it
  • discharge from the nipple
  • inversion or 'turning in' of the nipple (where not previously inverted)
  • flaking of skin
  • swelling of the upper arm or a swelling or lump in the armpit
  • pain in the breast (11).

Women who are eligible women should have a mammogram (an x-ray of the breasts) every two years (12).

Breast cancer screening policy

In 1991, the Australian Government launched the National Program for the Early Detection of Breast Cancer (now BreastScreen Australia), which aims to ensure that women in the relevant age groups have a mammogram every two years.

This national program is designed as a mammographic screening program for women who do not have any symptoms of breast cancer. While women aged 40-49 can have a mammogram, the program is primarily directed at women aged 50-69 (13). This is because mammograms are generally less effective at detecting early breast cancers in the denser breast tissue of younger women, as well as the fact that breast cancer becomes more common after 50. Women aged 70 and over are also eligible to participate if they wish to do so.

The age at which it is most effective to begin mammography has been the subject of considerable debate in a number of countries recently. Well-known Queensland breast cancer specialists have stated their belief that mammography for the whole 40-69 age group would be cost-effective(14)

Participation in screening

During the 2 year period 2003 & 2004, 1 627 115 women were screened by BreastScreen Australia. Participation among women aged 50-69 (the priority target group) was 55.6% (15). These figures do not include women screened outside of the BreastScreen Australia program, such as in private breast clinics.

Treatments for breast cancer

There are four main aspects to treatment. Most women have surgery, but other treatments depend on the type of cancer and the stage it has reached.

  • Surgery -  may involve the removal of just the tumour (lumpectomy), the tumour and part of the breast (partial mastectomy) or the whole breast (mastectomy). The lymph nodes may also be removed.
  • Radiotherapy -  the use of radiation to destroy any remaining cancer cells.
  • Chemotherapy - a course of powerful drugs intended to destroy cancer cells ;which may have spread to other parts of the body. Chemotherapy is generally given in several courses or cycles, with a rest period between each.
  • Hormone therapy - the hormone oestrogen, which occurs naturally in the body, appears to encourage the growth of breast cancer cells. Hormone therapy consists of a number of drugs that inhibit oestrogen from promoting cancer cell growth.

References

  1. Australian Institute of Health and Welfare & Australasian Association of Cancer Registries (AACR). Cancer in Australia: An overview, 2006 Canberra: AIHW 2007 p13
  2. Australian Institute of Health and Welfare & Australasian Association of Cancer Registries. Cancer in Australia: An overview, 2006 Ibid p43
  3. Australian Institute of Health and Welfare & Australasian Association of Cancer Registries. Cancer in Australia: An overview, 2006 Ibid p13
  4. Australian Institute of Health and Welfare & Australasian Association of Cancer Registries. Cancer in Australia: An overview, 2006 Ibid p49
  5. Australian Institute of Health and Welfare & Australasian Association of Cancer Registries. Cancer in Australia: an overview, 2006 Ibid p41
  6. Australian Institute of Health and Welfare & Australasian Association of Cancer Registries. Cancer in Australia: an overview, 2006 Ibid p56
  7. Australian Institute of Health and Welfare & National Breast Cancer Centre. Breast Cancer in Australia: An overview, 2006 Canberra: AIHW, 2006 p8
  8. National Breast Cancer Centre. Risk Factors www.nbcc.org.au/risk [website] date accessed: 24 October 2007
  9. NHMRC National Breast Cancer Centre & Australian Institute of Health and Welfare. Breast cancer in Australian Women 1921-1994 Canberra AIHW 1996 p2 
  10. Australian Institute of Health and Welfare & National Breast Cancer Centre. Breast Cancer in Australia: An overview, 2006 Ibid p43
  11. The Cancer Council Queensland. Early Detection of Breast Cancer
    http://www.cancerqld.org.au/reduce_risk/detection/early_detection.asp
    [website] date accessed: 24 October 2007
  12. The Cancer Council Queensland. Early Detection of Breast Cancer Ibid
  13. Coory, M & Byrne, D. Breast Cancer and Breast Screen Australia: Information Circular 48 Queensland Health 2000 p2
  14. Hirst C & Furnival C. The case for earlier screening Breast News Vol 2 No 2 1996 p4, 8
  15. Australian Institute of Health and Welfare. BreastScreen Australia Monitoring Report 2003-2004 Canberra: AIHW, 2007 p ix

For further information sources on this topic see our Internet resources for assignments page.

This student factsheet is one of a series produced by Women's Health Queensland Wide. They have been developed in response to students' most frequently asked questions and reflect a range of topics examined by high school and tertiary students. It has been reviewed by our Editorial Committee. This factsheet is designed for student assignment purposes and, therefore, may not be an appropriate source of information for personal use.

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Last Modified: October 30, 2007

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